Lymph node granulomas in immunoglobulin G4-related disease.

摘要: Aims Immunoglobulin (Ig)G4-related disease (IgG4-RD) is an increasingly recognized fibroinflammatory condition that commonly exhibits multisystem involvement, with localized (e.g. inflammatory pseudotumours can mimic malignancy) or diffuse (leading to organ dysfunction) patterns of tissue involvement. The 2012 Boston criteria have standardized the histopathological approach diagnosis IgG4-RD and require one more cardinal morphological features prominence IgG4+ plasma cells IgG4+/IgG+ cell ratio at least 40%. relative prevalence varies between anatomical sites, but granulomas are rarely found and, indeed, their presence would usually deter a pathologist from making this diagnosis. aim was characterize two cases in which were present highlight as unusual feature condition. Methods results We describe within lymph nodes, together granulomas. This rare pattern IgG4-RD. Conclusions While finding, should not preclude appropriate clinicopathological context.