Redox regulation and pro-oxidant reactions in the physiology of circadian systems.

摘要: Abstract Rhythms of approximately 24 h are pervasive in most organisms and known as circadian. There is a molecular circadian clock each cell sustained by feedback system interconnected “clock” genes transcription factors. In mammals, the timing formed central pacemaker, suprachiasmatic nucleus, coordination with collection peripheral oscillators. Recently, an extensive interconnection has been recognized between set biochemical pathways that underlie bioenergetics cell. A principle regulator metabolic networks flow electrons electron donors acceptors. The concomitant reduction oxidation (redox) reactions directly influence balance anabolic catabolic processes. This review summarizes discusses recent findings concerning mutual dynamic interactions clock, redox reactions, signaling. scope includes regulatory role played coenzymes (NAD(P)+/NAD(P)H, GSH/GSSG), reactive oxygen species (superoxide anion, hydrogen peroxide), antioxidants (melatonin), physiological events modulate state (feeding condition, rhythms) determining capacity clock. addition, we discuss purely which based on enzymes peroxiredoxins present mammalian red blood cells other biological systems. Both network key to better understanding widespread pathological conditions such syndrome, obesity, diabetes.