Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.
作者： Hae Jin Kee , Kyu Youn Ahn , Ki Choon Choi , Jung Won Song , Tag Heo
DOI: 10.1016/J.FEBSLET.2004.06.011
关键词:
摘要: Murine brain-specific angiogenesis inhibitor 1 and 2 (mBAI1, mBAI2) are involved in after cerebral ischemia. In this study, mBAI3 was cloned characterized. Northern Western blot analyses demonstrated a unique developmental expression pattern the brain. The level of brain peaked day birth, unlike mBAI1 mBAI2, which 10 days birth. situ hybridization showed same localization BAI3 as BAI1 BAI2, includes most neurons cortex hippocampus. vivo focal ischemia model, decreased from 0.5 h hypoxia until 8 h, but returned to control 24 h. vascular endothelial growth factor following an inverse pattern. expressions BAIs high-grade gliomas were observed, generally lower malignant than normal Our results indicate that distribution brain, not its expression, very similar those may participate early phases ischemia-induced tumor progression.
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