Vaccines based on whole recombinant Saccharomyces cerevisiae cells.

摘要: The ultimate goal of therapeutic vaccines is to activate and exploit the patient's own immune system vigorously dynamically seek eradicate established malignant or virally infected cells. Therapeutic also offer potential for preventing disease recurrence. Saccharomyces cerevisiae-based vaccines, where yeast engineered express viral tumor antigens, represent an ideal approach due their ability stimulate tumor- viral-specific CD4(+) CD8(+) T-cell responses that are capable reducing burden. This review describes preclinical clinical studies supporting development S. treatment cancer diseases, as well multimodal strategies in which combined with cytotoxic drugs achieve a greater response.