FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver
作者： Amélie Bravard , Guillaume Vial , Marie-Agnès Chauvin , Yves Rouillé , Bernard Bailleul
关键词:
摘要: … Interestingly, FTO overexpression also … liver mitochondria, resulting in an increase of mitochondria function and density. Altogether, these data indicate that FTO promotes mitochondrial …
biomedcentral.com
springer.com
paperity.org参考文章(44)
A K Groen, R C Vervoorn, R Van der Meer, J M Tager, Control of gluconeogenesis in rat liver cells. I. Kinetics of the individual enzymes and the effect of glucagon. Journal of Biological Chemistry. ,vol. 258, pp. 14346- 14353 ,(1983) , 10.1016/S0021-9258(17)43867-1
Jeffrey M. Friedman, Jeffrey L. Halaas, Leptin and the regulation of body weight in mammals Nature. ,vol. 395, pp. 763- 770 ,(1998) , 10.1038/27376
Ryohei Wakahara, Hiroyuki Kunimoto, Kanae Tanino, Hirotada Kojima, Akira Inoue, Haruo Shintaku, Koichi Nakajima, Phospho‐Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho‐Tyr705 largely through TC45 Genes to Cells. ,vol. 17, pp. 132- 145 ,(2012) , 10.1111/J.1365-2443.2011.01575.X
Hitomi Fukuda, Nobuko Iritani, Tomomi Sugimoto, Hitoshi Ikeda, Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats FEBS Journal. ,vol. 260, pp. 505- 511 ,(2001) , 10.1046/J.1432-1327.1999.00183.X
Yi-Chun Loraine Tung, Giles S. H. Yeo, From GWAS to biology: lessons from FTO Annals of the New York Academy of Sciences. ,vol. 1220, pp. 162- 171 ,(2011) , 10.1111/J.1749-6632.2010.05903.X
Yi-Chun Loraine Tung, Eduard Ayuso, Xiaoye Shan, Fatima Bosch, Stephen O'Rahilly, Anthony P. Coll, Giles S. H. Yeo, Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats PLoS ONE. ,vol. 5, pp. e8771- ,(2010) , 10.1371/JOURNAL.PONE.0008771
Tea Berulava, Bernhard Horsthemke, The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels European Journal of Human Genetics. ,vol. 18, pp. 1054- 1056 ,(2010) , 10.1038/EJHG.2010.71
Sandrine Belouzard, Delphine Delcroix, Yves Rouillé, Low Levels of Expression of Leptin Receptor at the Cell Surface Result from Constitutive Endocytosis and Intracellular Retention in the Biosynthetic Pathway Journal of Biological Chemistry. ,vol. 279, pp. 28499- 28508 ,(2004) , 10.1074/JBC.M400508200
Chien-Ping Liang, Alan R. Tall, Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver. Journal of Biological Chemistry. ,vol. 276, pp. 49066- 49076 ,(2001) , 10.1074/JBC.M107250200
Maria H. Holmström, Robby Zachariah Tom, Marie Björnholm, Pablo M. Garcia-Roves, Juleen R. Zierath, Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice Metabolism-clinical and Experimental. ,vol. 62, pp. 1258- 1267 ,(2013) , 10.1016/J.METABOL.2013.04.001