Meningoencephalitis and Demyelination Are Pathologic Manifestations of Primary Polyomavirus Infection in Immunosuppressed Rhesus Monkeys

摘要: The human polyomavirus JC (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy (PML), a demyelinating disease CNS that occurs in immunosuppressed individuals. Because polyomavirus-induced pathology usually as result reactivation latent virus, little known about manifestations primary man. To model such infection, SV40-negative rhesus monkeys were by infection with virus SHIV-89.6P and then superinfected SV40. animals developed characterized both demyelination meningoencephalitis. This observation suggests can be associated an inflammatory process. These data shed new light on pathogenic mechanisms primate polyomaviruses immunocompromised host.