Effect of Pravastatin on Coronary Disease Events in Subgroups Defined by Coronary Risk Factors The Prospective Pravastatin Pooling Project

摘要: Background—Previous trials have had insufficient numbers of coronary events to address definitively the effect lipid-modifying therapy on heart disease in subgroups patients with varying baseline characteristics. Methods and Results—The data from 3 large randomized pravastatin 40 mg were pooled analyzed use a prospectively defined protocol. Included 19 768 patients, 102 559 person-years follow-up, 2194 primary end points (coronary death or nonfatal myocardial infarction), 3717 expanded (primary point, CABG, PTCA). Pravastatin significantly reduced relative risk younger (<65 years) older (≥65 men women, smokers nonsmokers, without diabetes hypertension. The was smaller, but absolute reduction similar hypertension compared those Relative significant predefined categories lipid co...