Serum bile acid concentrations during pregnancy and their relationship to obstetric cholestasis.

摘要: We have prospectively studied changes in serum postprandial cholylglycine (CG) concentration during 297 pregnancies. found an increase CG from 0.3 mumol/L at 15 weeks' pregnancy to 0.6 40 pregnancy. Although this was statistically significant (p less than 0.005), median concentrations of remained well within the normal range (0-1.5 mumol/L). However, 10% group showed markedly elevated 30 pregnancy, and level continued rise third trimester. Pruritus significantly more common with (48%) levels (20%) 0.005). Serum a much sensitive predictor pruritus other biochemical liver tests. Elevated were commonly Mediterranean Asian patients ethnic origins 0.025). No associations between maternal age, number previous pregnancies, contraceptive-induced cholestasis, fetal maturity. conclude that obstetric cholestasis is probably previously suspected consideration should be given measurement bile acids all pregnant individuals unexplained pruritus.