7-Alkyl- and 7-Cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines—potent inhibitors of the tyrosine kinase c-Src
作者： Leo Widler , Jonathan Green , Martin Missbach , Mira Šuša , Eva Altmann
DOI: 10.1016/S0960-894X(01)00079-8
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摘要: Abstract 7-Substituted-5-aryl-pyrrolo[2,3- d ]pyrimidines have been prepared starting from α-bromoacetophenones. These compounds represent a novel class of potent inhibitors the tyrosine kinase pp60 c-Src with good specificity towards other kinases (EGF-R, v-Abl).
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