Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans.
作者： Paul J Norman , Laurent Abi-Rached , Ketevan Gendzekhadze , Daniel Korbel , Michael Gleimer
DOI: 10.1038/NG2111
关键词:
摘要: Interactions of killer cell immunoglobulin-like receptors (KIRs) with major histocompatibility complex (MHC) class I ligands diversify natural responses to infection. By analyzing sequence variation in diverse human populations, we show that the KIR3DL1/S1 locus encodes two lineages polymorphic inhibitory KIR3DL1 allotypes recognize Bw4 epitopes protein">HLA-A and HLA-B one lineage conserved activating KIR3DS1 allotypes, also implicated recognition. Balancing selection has maintained these three for over 3 million years. Variation was selected at D1 D2 domain residues contact HLA sites on D0, enhances binding KIR3D I. variants gained through interallelic microconversion are products selection. A worldwide comparison uncovers unusual evolution modern sub-Saharan Africans. is weak confined rare similar predominate. Natural cells express dominant a high frequency surface density, providing strong perturbed expression.
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