Novel KIR3DL1 Alleles and Their Expression Levels on NK Cells: Convergent Evolution of KIR3DL1 Phenotype Variation?
作者： Rasmi Thomas , Eriko Yamada , Galit Alter , Maureen P. Martin , Arman A. Bashirova
DOI: 10.4049/JIMMUNOL.180.10.6743
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摘要: KIR3DL1 shows extensive polymorphism, and its variation has functional significance in terms of cell-surface expression levels inhibitory capacity. We characterized nine alleles (*022, *028, *029, *033, *035, *051, *052, *053, *054), four which were identified for the first time this study, compared them to known phylogenetic analysis. Blood was available from eight individuals with these alleles, on NK cells could be determined six using KIR3DL1-specific Ab DX9. Four expressed at clearly detectable levels, two others showed exceptionally low expression. Site-directed mutagenesis demonstrated that single amino acid changes can result either diminished or enhanced DX9 staining respective related allotypes. These results raise possibility evolution maintains potentially due effect such
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