Retrospective comparison of the effectiveness of various treatment modalities of extragastric MALT lymphoma: a single-center analysis

摘要: We have performed a retrospective analysis of all patients with extragastric mucosa-associated lymphoid tissue (MALT) lymphoma treated at our institution to compare the efficacy first-line therapeutic modalities including surgery, radiation, systemic therapy, and antibiotics. One hundred eighty-five MALT median age 63 (interquartile range (IQR) 50-74) years follow-up time 49 (IQR 18-103) months were retrospectively analyzed. Time progression next therapy used as surrogate endpoints for efficacy. Patients having either surgery (100 %), chemo/immunotherapy (85.5 or radiation (80 %) had significantly (p = 0.01) higher response rates than antibiotics (33.3 %). who irradiated more progressive disease, but also longest time. Stage, elevated LDH, anemia, beta-2 microglobulin, plasmacytic differentiation, monoclonal gammopathy, autoimmune disease did not influence rate nor complete remission partial from initial progression. There was no significant difference in 0.141), estimated 0.023) well 0.021) different among various cohorts favoring chemo/immunotherapy, radiation. Our results suggest potential irrespective stage. Radiation, seem be equally effective achieving remissions prolonged free survivals, curative is questionable. Localized lymphomas affecting thyroid gland lungs excellent long-term progression-free survivals surgical treatment only.