Alternative therapies for diabetes and its cardiac complications: role of vanadium

作者: Tod A. Clark , Justin F. Deniset , Clayton E. Heyliger , Grant N. Pierce

DOI: 10.1007/S10741-013-9380-0

关键词:

摘要: It is now well known that a cardiomyopathic state accompanies diabetes mellitus. Although insulin injections and conventional hypoglycemic drug therapy have been of invaluable help in reducing cardiac damage dysfunction diabetes, failure continues to be common cause death the diabetic population. The use alternative medicine maintain health treat variety diseases has achieved increasing popularity recent years. goal therapies patients lower circulating blood glucose levels thereby complications. This paper will focus its discussion on role vanadium associated dysfunction. Careful administration forms produced impressive long-lasting control both Type 1 2 animals. accompanied by, many cases, complete correction cardiomyopathy. oral delivery as vanadate salt presence tea particularly effects restoration function. intriguing approach treatment complications, however, deserves further intense investigation prior for complications due unknown long-term accumulation heart other organs body.

参考文章(128)
Natesanpillai Sekar, Anumanthan Kanthasamy, Samuel William, Natarajan Balasubramaniyan, Saminathan Govindasamy, Antioxidant effect of vanadate on experimental diabetic rats. Acta Diabetologica. ,vol. 27, pp. 285- 293 ,(1990) , 10.1007/BF02580932
Tod A Clark, Andrea L Edel, Clayton E Heyliger, Grant N Pierce, Effective control of glycemic status and toxicity in Zucker diabetic fatty rats with an orally administered vanadate compound. Canadian Journal of Physiology and Pharmacology. ,vol. 82, pp. 888- 894 ,(2004) , 10.1139/Y04-109
Tod A. Clark, Thane G. Maddaford, Paramjit S. Tappia, Clayton E. Heyliger, Pallab K. Ganguly, Grant N. Pierce, Restoration of Cardiomyocyte Function in Streptozotocin-Induced Diabetic Rats after Treatment with Vanadate in a Tea Decoction Current Pharmaceutical Biotechnology. ,vol. 11, pp. 906- 910 ,(2010) , 10.2174/138920110793261999
Supriya Ganguli, Donald J. Reuland, LeRoy A. Franklin, Mark Tucker, Effect of vanadate on reproductive efficiency in normal and streptozocin-treated diabetic rats Metabolism-clinical and Experimental. ,vol. 43, pp. 1384- 1388 ,(1994) , 10.1016/0026-0495(94)90032-9
Rodney J. French, Peter J.H. Jones, Role of vanadium in nutrition: Metabolism, essentiality and dietary considerations Life Sciences. ,vol. 52, pp. 339- 346 ,(1993) , 10.1016/0024-3205(93)90146-T
TAKAKO YOKOZAWA, TAKAKO NAKAGAWA, KYEOUNG IM LEE, EUN JU CHO, KATSUTOSHI TERASAWA, SHIGEYA TAKEUCHI, Effects of Green Tea Tannin on Cisplatin‐induced Nephropathy in LLC‐PK1 Cells and Rats Journal of Pharmacy and Pharmacology. ,vol. 51, pp. 1325- 1331 ,(2010) , 10.1211/0022357991776912
Dominique J. Becker, Lumber-Njadi Ongemba, Jean-Claude Henquin, Comparison of the effects of various vanadium salts on glucose homeostasis in streptozotocin-diabetic rats European Journal of Pharmacology. ,vol. 260, pp. 169- 175 ,(1994) , 10.1016/0014-2999(94)90334-4
Michio Ui, Taro Okada, Kaoru Hazeki, Osamu Hazeki, Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase Trends in Biochemical Sciences. ,vol. 20, pp. 303- 307 ,(1995) , 10.1016/S0968-0004(00)89056-8
Taku Matsubara, Sorin Musat-Marcu, Hara P. Misra, Naranjan S. Dhalla, Protective effect of vanadate on oxyradical-induced changes in isolated perfused heart. Molecular and Cellular Biochemistry. ,vol. 153, pp. 79- 85 ,(1995) , 10.1007/BF01075921