Neuropathology of the acquired immune deficiency syndrome (AIDS): a report of 135 consecutive autopsy cases from Switzerland.

摘要: Neuropathological changes were studied in a consecutive autopsy series of 135 cases, comprising 73% all patients who died AIDS Switzerland between April 1981 and December 1987. Central nervous system involvement was found 119 (88%), 19 which had multiple concomitant intracerebral lesions. Among the non-viral opportunistic infections, encephalitis due toToxoplasma gondii most frequent occurred 35 (26%), followed by central infection withCryptococcus neoformans, five (4%). Cytomegalovirus (CMV) present 14 (10%). Disseminated microglial nodules without morphological or immunocytochemical evidence CMV encountered 18 (13%). However, but two these there extracerebral infection, suggesting that responsible for nodular encephalitides. Nine (7%) progressive multifocal leukoencephalopathy (PML); these, demyelination associated with extensive tissue destruction cyst formation. HIV-associated encephalopathy observed 21 (16%) showed characteristic patterns: diffuse (PDL) giant cell (MGCE). PDL 13 cases characterized pallor gliosis cerebral cerebellar white matter scattered multinucleated cells, significant inflammatory response. MGCE eight clusters numerous rod macrophages, lymphocytic infiltrates occasional necroses. In our view, represent opposite variants HIV-induced encephalopathies, overlapping intermediate manifestations.