Palliative radiotherapy for metastatic malignant melanoma: Brain metastases, bone metastases, and spinal cord compression

摘要: Abstract The records of all patients receiving palliative radiotherapy for malignant melanoma metastatic to brain, bone, or with spinal cord compression were reviewed. median survival 77 brain metastases from the initiation was 14 weeks. A statistically improved observed only in 10 who underwent subtotal total resection a solitary metastasis prior (median = 36 weeks). No 12 treated by alone 16 Multivariate analysis revealed that fraction size, dose, patient age, sex, and duration interval between initial diagnosis appearance did not significantly influence survival, but use chemotherapy associated decreased survival. Twenty six symptomatic radiographic evidence 39 bone showed response rate 85%. 18 20 bony lesions high-dose-per-fraction (≥400 cGy) 15 19 conventional fractionation (≤300 palliated. Total metastases, concurrent chemotherapy, lesion location palliation. Seventeen identified myelographic compression. Complete palliation 47% (817) partial 24% (417). overall neurologic symptoms due 71% appeared be independent size dose.