Posttranslational Modification of Constitutive Nitric Oxide Synthase in the Penis

摘要: Erectile dysfunction (ED) is a common men's health problem characterized by the consistent inability to sustain an erection sufficient for sexual intercourse. Basic science research on erectile physiology has been devoted investigating pathogenesis of ED and led conclusion that predominately disease vascular origin, neurogenic dysfunction, or both. The constitutive forms nitric oxide synthase (NOS, endothelial [eNOS] neuronal [nNOS]) are important enzymes involved in production (NO) thus regulate penile homeostasis. Given effect endothelial- neuronal-derived NO biology, great deal over past decade focused role synthesis from endothelium nitrergic nerve terminal normal physiology, as well states. Loss functional integrity subsequent plays integral occurrence ED. Therefore, molecular mechanisms dysregulation these NOS isoforms development essential discovering various This communication reviews eNOS nNOS discusses alterations via posttranslation modification diseases penis.