A molecule and chimeric molecules thereof
作者： John D Priest , Ingrid Boehm , Jason S. Whittaker , Raina J. Simpson , Alan D. Watts
DOI:
关键词:
摘要: The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, provides an isolated protein molecule in or related tumour necrosis factor (TNF) superfamily such as TNF-a, Lymphotoxin-a (LT-a), TNFRI, TNFRII, OX40, BAFF, NGFR, Fas Ligand chimeric molecules thereof comprising at least a portion molecule, TNF-a-Fc, LT-a-Fc, TNFRI-Fc, TNFRII-Fc, OX40-Fc, BAFF-Fc, NGFR-Fc, Ligand-Fc; wherein has profile measurable physiochemical parameters, is indicative of, associated with forms basis one more pharmacological traits. further contemplates use range diagnostic, prophylactic, therapeutic, nutritional and/or research applications.
lens.org参考文章(122)
Michael Bavand, Horst Blasey, Process for the production and purification of erythropoietin ,(2002)
Weijing Zhang, Dezheng Wu, Xinjiang Du, Gang Chen, Shirley X. Chen, Therapeutic use of tumor necrosis factor-alpha mutein ,(2003)
Rebecca E. Mccoy, Richard L. Remmele, Helmut M. Sassenfeld, Increased recovery of active proteins ,(2002)
Daniel R. Marsh, Sharon T. Wong, Susan O. Meakin, James I. S. MacDonald, Eilis F. Hamilton, Lynne C. Weaver, Neutralizing intraspinal nerve growth factor with a trkA-IgG fusion protein blocks the development of autonomic dysreflexia in a clip-compression model of spinal cord injury. Journal of Neurotrauma. ,vol. 19, pp. 1531- 1541 ,(2002) , 10.1089/089771502762300201
Rocco Savino, Gennaro Ciliberto, Nicola La Monica, Adenoviral vectors encoding erythropoietin and their use in gene therapy ,(1999)
C. A. Smith, R. G. Goodwin, V. P. Fung, D. S. Torrance, Hassan Madani, K. E. Stremler, K. M. Mohler, M. B. Widmer, Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. Journal of Immunology. ,vol. 151, pp. 1548- 1561 ,(1993)
Peter W. Nickerson, Wayne W. Hancock, Alan W. Steele, Kensaku Kawamoto, Yongsheng Li, Xian Chang Li, Xin Xiao Zheng, Yan Tian, Terry B. Strom, IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice. Journal of Immunology. ,vol. 163, pp. 4041- 4048 ,(1999)
Russell P. Rother, Stephen P. Squinto, Dayang Wu, Susan Faas-Knight, Mark J. Evans, Antibodies and fusion proteins that include engineered constant regions ,(2004)
Nancy I. Minster, John P. Mc Kearn, Yiqing Feng, Neena L. Summers, Philip R. Streeter, John C. Minnerly, Charles A. McWherter, Nicholas R. Staten, Susan L. Woulfe, Multi-functional chimeric hematopoietic receptor agonists ,(1997)
Julie A. Morris, Jeffrey C. Rapp, Guodong Liu, Robert D. Ivarie, Alex J. Harvey, Exogenous proteins expressed in avians and their eggs ,(2004)