Effects of aging per se on arterial stiffness: Systemic and regional compliance in beagles

摘要: Abstract Although previous studies have suggested that aging results in an increase vascular stiffness, diseases prevalence with advanced age may confounded the of some this past research. The purpose investigation was to determine whether per se reduced arterial compliance by using animals are resistant atherosclerosis and do not develop hypertension or hyperlipidemias age. We evaluated systemic regional (femoral) older (110 ± 8 months old) younger (27 2 female beagle dogs a computer-based assessment diastolic decay pressure waveforms modified Windkessel model circulation. very similar both groups, cardiac output 29% lower ( p = 0.03) resistance 24% higher 0.02) dogs. Moreover, there age-related reduction compliance, derived from exponential pulse (C 1 ) 0.05) oscillatory component wave 0.04). By contrast, although femoral 25% 0.04), measured after occlusion also but significantly changed 0.14). These demonstrate is dogs, extending finding without frequently occur human beings. Regional isolated bed, tends be age, variability parameter reduces significance finding.