PrediagnosticHelicobacter pyloriAntibodies and Colorectal Cancer Risk in an Elderly, Caucasian Population

摘要: Background Study results on overall seroprevalence of Helicobacter pylori and colorectal cancer risk have been inconsistent. However, one study found positive associations with antibodies to specific H. proteins. To follow up those findings, we assessed 15 proteins incidence in the prospective Cancer Prevention Study-II Nutrition Cohort. Materials Methods Participants this nested case–control included 392 cases 774 controls who were predominantly elderly (median age at blood draw: 71 years) Caucasian (98%). Seroreactivity against was by fluorescent bead-based multiplex serology estimated using conditional logistic regression. Results Helicobacter serostatus not associated (odds ratio (OR), 1.17, 95% confidence interval (95% CI), 0.91–1.50). Among individual antigens, GroEl (OR, 1.32, CI: 1.03–1.70), whereas CagM colon only 1.35, 1.01–1.80). No dose–response relationships observed for any including CagM. Conclusions The our do support an association between infection elderly, mostly population.