Present status of clinical proteomic analysis for the early detection and determination of therapeutic strategy in lung cancer.
作者： Harubumi Kato , Takashi Hirano
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摘要: Although human DNA sequences have already been successfully decoded, there is still much we do not understand about the pathogenesis of diseases. Proteomic analysis comprehensive proteins, and a high probability that recent advances in this field will enable its application to individualized therapy based on thorough understanding Two-dimensional polyacrylamide gel electrophoresis (2-DE) mass spectrometry (MS) are indispensable tools for proteomic analysis, these technologies discovery tiny changes protein expression associated with pathogenesis. In review introduce present status cancer-related especially lung proteins attempt discover new biomarkers early detection determine novel target-molecules treatment. We believe provide crucial information diagnosis
atcs.jp 参考文章(21)
Yu-Chang Tyan, Hsin-Yi Wu, Wu-Wei Lai, Wu-Chou Su, Pao-Chi Liao, Proteomic profiling of human pleural effusion using two-dimensional nano liquid chromatography tandem mass spectrometry. Journal of Proteome Research. ,vol. 4, pp. 1274- 1286 ,(2005) , 10.1021/PR049746C
T Hirano, B Franzén, K Uryu, K Okuzawa, AA Alaiya, F Vanky, L Rodrigues, Y Ebihara, H Kato, G Auer, Detection of polypeptides associated with the histopathological differentiation of primary lung carcinoma. British Journal of Cancer. ,vol. 72, pp. 840- 848 ,(1995) , 10.1038/BJC.1995.422
Kiyonaga Fujii, Tomoyo Nakano, Mitsuhiro Kanazawa, Shingo Akimoto, Takashi Hirano, Harubumi Kato, Toshihide Nishimura, Clinical-scale high-throughput human plasma proteome analysis: Lung adenocarcinoma Proteomics. ,vol. 5, pp. 1150- 1159 ,(2005) , 10.1002/PMIC.200401145
Marc R. Wilkins, Jean-Charles Sanchez, Keith L. Williams, Denis F. Hochstrasser, Current challenges and future applications for protein maps and post‐translational vector maps in proteome projects Electrophoresis. ,vol. 17, pp. 830- 838 ,(1996) , 10.1002/ELPS.1150170504
Takashi Hirano, Gert Auer, Masahiro Maeda, Yoshiaki Hagiwara, Shinya Okada, Tatsuo Ohira, Ken Okuzawa, Kaoru Fujioka, Bo Franzén, Nozomu Hibi, Tsutomu Seito, Yoshiro Ebihara, Harubumi Kato, Human Tissue Distribution of TA02, Which is Homologous with a New Type of Aspartic Proteinase, Napsin A Japanese Journal of Cancer Research. ,vol. 91, pp. 1015- 1021 ,(2000) , 10.1111/J.1349-7006.2000.TB00879.X
Bo Franzén, Stig Linder, Ken Okuzawa, Harabumi Kato, Gert Auer, Nonenzymatic extraction of cells from clinical tumor material for analysis of gene expression by two‐dimensional polyacrylamide gel electrophoresis Electrophoresis. ,vol. 14, pp. 1045- 1053 ,(1993) , 10.1002/ELPS.11501401167
Takayuki Ueno, Stig Linder, Cheng-Lun Na, Ward R. Rice, Jan Johansson, Timothy E. Weaver, Processing of pulmonary surfactant protein B by napsin and cathepsin H Journal of Biological Chemistry. ,vol. 279, pp. 16178- 16184 ,(2004) , 10.1074/JBC.M312029200
Jane M. C. Oh, Franck Brichory, Eric Puravs, Rork Kuick, Chris Wood, Jean Marie Rouillard, John Tra, Sharon Kardia, David Beer, Samir Hanash, A database of protein expression in lung cancer. Proteomics. ,vol. 1, pp. 1303- 1319 ,(2001) , 10.1002/1615-9861(200110)1:10<1303::AID-PROT1303>3.0.CO;2-2
Yue Hu, Suzhan Zhang, Jiekai Yu, Jian Liu, Shu Zheng, SELDI-TOF-MS: the proteomics and bioinformatics approaches in the diagnosis of breast cancer. The Breast. ,vol. 14, pp. 250- 255 ,(2005) , 10.1016/J.BREAST.2005.01.008
Yaxin Zheng, Ye Xu, Bin Ye, Junyi Lei, Michael H Weinstein, Michael P O'Leary, Jerome P Richie, Samuel C Mok, Brian C‐S Liu, None, Prostate carcinoma tissue proteomics for biomarker discovery Cancer. ,vol. 98, pp. 2576- 2582 ,(2003) , 10.1002/CNCR.11849