Studies in Carcinogenesis: VIII. Experimental Production of Brain Tumors in Mice with Methylcholanthrene

摘要: The experimental production of skin cancer in laboratory animals with coal tar (Yamagiwa and Ichikawa, 1915) a pure hydrocarbon known structure (Kennaway Hieger, 1930) has led to the development many lines inquiry. One these been study relationship chemical carcinogenic activity. Another determination types tissue which are susceptible action such compounds. Malignant tumors have produced experimentally various tissues several species by direct contact carcinogens (see summaries Cook coworkers, 1937, Kennaway, 1938). investigation be reported here, response central nervous system treatment, was undertaken 1935. A number investigators introduced materials into brains animals. According an emulsion injected subarachnoid space rabbits Pigalew (1928), but no mention made brain lesions. Roussy, Oberling, Raileanu (1930) applied gauze impregnated surface obtained necrosis tissue. Guerin (1936) placed crystal benzpyrene cortex 10 rats, oil solution another rat. Hypophyseal adenomas developed 3 rats that lived for more than ten months; animal had received bore epitheliomatous hypophyseal tumor. Ilfeld implanted 5 per cent dibenzanthracene-cholesterol pellet cerebral each 2 market mice negative results after eight months.