Coactivator and corepressor complexes in nuclear receptor function.
作者： Lan Xu , Christopher K Glass , Michael G Rosenfeld
DOI: 10.1016/S0959-437X(99)80021-5
关键词:
摘要: The nuclear hormone receptors constitute a large family of transcription factors. binding the hormonal ligands induces to assume configuration that leads transcriptional activation. Recent studies retinoic acid and thyroid revealed that, upon ligand binding, histone deacetylase (HDAC)-containing complex is displaced from receptor in exchange for acetyltransferase (HAT)-containing complex. These observations suggest ligand-dependent recruitment chromatin-remodeling activity serves as general mechanism underlying switch being transcriptionally repressive active.
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