Studies on luteinizing hormone and its subunits: development and application of a radioligand receptor assay and properties of the hormone-receptor interaction.
作者： C.G. TROWBRIDGE , LEO E. REICHERT , FREIMUT LEIDENBERGER
DOI: 10.1016/B978-0-12-571129-6.50017-8
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摘要: Publisher Summary This chapter presents studies on luteinizing hormone (LH) and its subunits. It also describes the development application of a radioligand receptor assay properties hormone-receptor interaction. The use biological assays for gonadotropins has progressed from earlier qualitative tests to more modern quantitative approaches. Biological suffer ubiquitous unavoidable problems related whole animals, which are reflected by lack adequate sensitivity relatively poor precision. high affinity target tissues tropic hormones offers possibility sensitive, highly specific, precise in vitro bioassays, utilizing principles competitive protein binding-saturation analysis. Such systems would have advantages relative independence factors plasma half-life vivo metabolism allow structure-function that might not be feasible if animal were only ones available. discusses this system quantitation LH activity human pituitary fractions, fundamental aspects binding, relationships LH.
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