Expression of copper-related genes in response to copper load

作者: Mauricio González , Angélica Reyes-Jara , Miriam Suazo , William J Jo , Chris Vulpe

DOI: 10.1093/AJCN/88.3.830S

关键词:

摘要: Copper is an essential micronutrient for all biological systems. Multiple proteins require one or more atoms of copper proper structure and function, but excess toxic. To prevent the consequences deficiency overload, living organisms have evolved molecular mechanisms that regulate its uptake, intracellular traffic, storage, efflux. Underlying some cellular responses to variations in levels are changes expression genes encoding components metabolism. In recent years, genome-scale analysis several eukaryotic models has allowed identification copper-responsive involved homeostasis. Characterization transcriptional response varying include both directly homeostasis different process that, even though they not connected metabolism, change their during adaptation availability. Evaluation these gene patterns could aid biologically relevant markers monitor status humans.

参考文章(49)
Jeane De Freitas, Henri Wintz, J Hyoun Kim, Helen Poynton, Tama Fox, Chris Vulpe, Yeast, a model organism for iron and copper metabolism studies. Biometals. ,vol. 16, pp. 185- 197 ,(2003) , 10.1023/A:1020771000746
J H Freedman, M R Ciriolo, J Peisach, The role of glutathione in copper metabolism and toxicity. Journal of Biological Chemistry. ,vol. 264, pp. 5598- 5605 ,(1989) , 10.1016/S0021-9258(18)83589-X
Deborah M Simpson, Ali Mobasheri, Susan Haywood, Robert J Beynon, A proteomics study of the response of North Ronaldsay sheep to copper challenge BMC Veterinary Research. ,vol. 2, pp. 36- 36 ,(2006) , 10.1186/1746-6148-2-36
Miriam Suazo, Felipe Olivares, Marco A. Mendez, Rodrigo Pulgar, Joseph R. Prohaska, Miguel Arredondo, Fernando Pizarro, Manuel Olivares, Magdalena Araya, Mauricio González, CCS and SOD1 mRNA are reduced after copper supplementation in peripheral mononuclear cells of individuals with high serum ceruloplasmin concentration. Journal of Nutritional Biochemistry. ,vol. 19, pp. 269- 274 ,(2008) , 10.1016/J.JNUTBIO.2007.04.003
Susanne Strand, Walter J. Hofmann, Annette Grambihler, Hubert Hug, Martin Volkmann, Gerd Otto, Horst Wesch, Sara M. Mariani, Volker Hack, Wolfgang Stremmel, Peter H. Krammer, Peter R. Galle, Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1/Fas) mediated apoptosis. Nature Medicine. ,vol. 4, pp. 588- 593 ,(1998) , 10.1038/NM0598-588
Sergi Puig, Dennis J Thiele, Molecular mechanisms of copper uptake and distribution Current Opinion in Chemical Biology. ,vol. 6, pp. 171- 180 ,(2002) , 10.1016/S1367-5931(02)00298-3
B. Zhou, J. Gitschier, hCTR1: A human gene for copper uptake identified by complementation in yeast Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 7481- 7486 ,(1997) , 10.1073/PNAS.94.14.7481
Ting Y. Tao, Fengli Liu, Leo Klomp, Cisca Wijmenga, Jonathan D. Gitlin, The Copper Toxicosis Gene Product Murr1 Directly Interacts with the Wilson Disease Protein Journal of Biological Chemistry. ,vol. 278, pp. 41593- 41596 ,(2003) , 10.1074/JBC.C300391200
Miguel Arredondo, Patricia Muñoz, Casilda V. Mura, Marco T. Núñez, DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells. American Journal of Physiology-cell Physiology. ,vol. 284, ,(2003) , 10.1152/AJPCELL.00480.2002