作者: Mauricio González , Angélica Reyes-Jara , Miriam Suazo , William J Jo , Chris Vulpe
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摘要: Copper is an essential micronutrient for all biological systems. Multiple proteins require one or more atoms of copper proper structure and function, but excess toxic. To prevent the consequences deficiency overload, living organisms have evolved molecular mechanisms that regulate its uptake, intracellular traffic, storage, efflux. Underlying some cellular responses to variations in levels are changes expression genes encoding components metabolism. In recent years, genome-scale analysis several eukaryotic models has allowed identification copper-responsive involved homeostasis. Characterization transcriptional response varying include both directly homeostasis different process that, even though they not connected metabolism, change their during adaptation availability. Evaluation these gene patterns could aid biologically relevant markers monitor status humans.