Intraperitoneal photodynamic therapy: comparison of red and green light distribution and toxicity.

摘要: The aim of this study was to compare red (652 nm) and green (514 light for photodynamic therapy (PDT) the peritoneal cavity with emphasis on distribution toxicity. Red-light PDT limited by intestinal toxicity it hypothesized that less penetrating would allow higher doses be used in cavity. Female non-tumor-bearing rats were photosensitized mTHPC (meta-tetrahydroxyphenylchlorin, Foscan) intravenously or intraperitoneally peritoneum illuminated using a minimally invasive technique. For both light, time illumination varied give required dose. Light fluence rate measured situ at multiple sites within abdominal experiments carried out total 160 J incident 640 drug dose 0.15 mg/kg Foscan. mean 55.2 +/- 38.5 mW cm-2 measured, peak 128 intestines. rates 8.2 9.0 (i.e. including zero measurements) 28 cm-2, respectively. Intestines most vulnerable illumination. intravenous injection route resulted increased but there no major differences between intraperitoneal routes. 4 h interval very little wavelengths. We conclude allows than over is much favorable may not suitable whole minimal-access