Intraperitoneal photodynamic therapy in the rat: Comparison of toxicity profiles for photofrin and mTHPC

摘要: Toxicity studies for intraperitoneal photodynamic therapy (IPPDT) were performed in Wag/RijA rats, using specially designed light delivery blocks proper distribution and dosimetry. A recently developed photosensitizer mesotetrahydroxyphenylchlorin (mTHPC), excited at 652-nm wavelength, was compared with Photofrin (630 nm). profiles various sensitizer doses, fluences time intervals investigated. fluence of 15 J - cm−2 delivered to the entire peritoneum 24 hr after 5 mg per kg i.v. induced reversible impairment intestinal, liver kidney function. dose 0.2 mTHPC followed by 6 · 72 appeared be equitoxic intestines; however, functional tests revealed little effect this mTHPC-mediated IPPDT regime on or kidney. Histology demonstrated focal irreversible damage kidneys both photosensitizers, not reflected impairment. Light doses 25 30 J. 8–12 cm−2, caused lethal toxicity first 2 weeks due intestinal damage. Higher a shock syndrome rhabdomyolysis resulting death within 20 photosensitizers. In conclusion, maximum tolerable schedules whole-abdomen defined mTHPC. Both photosensitizers cause similar depending drug dose, interval.