Foretinib Inhibits Cancer Stemness and Gastric Cancer Cell Proliferation by Decreasing CD44 and c-MET Signaling.

作者: Sung-Hwa Sohn , Bohyun Kim , Hee Jung Sul , Bo Youn Choi , Hyeong Su Kim

DOI: 10.2147/OTT.S226951

关键词:

摘要: … Indeed, foretinib inhibited angiogenesis, Wnt/β-catenin signaling, and the PI3K/Akt pathway in this study by inhibiting VEGFA, HIF-1α, c-MET, and AKT phosphorylation, as well as …

参考文章(63)
I Sporea, Marioara Cornianu, Corina Vernic, Sorina Tăban, Daniela Lazăr, Carmen Ardeleanu, Cristiana Simionescu, Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. Romanian Journal of Morphology and Embryology. ,vol. 49, pp. 371- 379 ,(2008)
Hisato Kawakami, Isamu Okamoto, Tokuzo Arao, Wataru Okamoto, Kazuko Matsumoto, Hirokazu Taniguchi, Kiyoko Kuwata, Haruka Yamaguchi, Kazuto Nishio, Kazuhiko Nakagawa, Yasuhide Yamada, MET amplification as a potential therapeutic target in gastric cancer. Oncotarget. ,vol. 4, pp. 9- 17 ,(2013) , 10.18632/ONCOTARGET.718
L Vermeulen, M R Sprick, K Kemper, G Stassi, J P Medema, Cancer stem cells – old concepts, new insights Cell Death & Differentiation. ,vol. 15, pp. 947- 958 ,(2008) , 10.1038/CDD.2008.20
Collene R. Jeter, Tao Yang, Junchen Wang, Hsueh-Ping Chao, Dean G. Tang, Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding Questions. Stem Cells. ,vol. 33, pp. 2381- 2390 ,(2015) , 10.1002/STEM.2007
Masakazu Nakajima, Hidetomo Sawada, Yukishige Yamada, Akihiko Watanabe, Mitsutoshi Tatsumi, Jun Yamashita, Masahiko Matsuda, Teruyuki Sakaguchi, Tomoko Hirao, Hiroshige Nakano, The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas. Cancer. ,vol. 85, pp. 1894- 1902 ,(1999) , 10.1002/(SICI)1097-0142(19990501)85:9<1894::AID-CNCR3>3.0.CO;2-J
Michael F Clarke, John E Dick, Peter B Dirks, Connie J Eaves, Catriona HM Jamieson, D Leanne Jones, Jane Visvader, Irving L Weissman, Geoffrey M Wahl, None, Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Research. ,vol. 66, pp. 9339- 9344 ,(2006) , 10.1158/0008-5472.CAN-06-3126
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Rock Bum Kim, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha, CD44 Variant 9 Serves as a Poor Prognostic Marker in Early Gastric Cancer, But Not in Advanced Gastric Cancer. Cancer Research and Treatment. ,vol. 48, pp. 142- 152 ,(2015) , 10.4143/CRT.2014.227
Tong-Chuan He, Andrew B Sparks, Carlo Rago, Heiko Hermeking, Leigh Zawel, Luis T Da Costa, Patrice J Morin, Bert Vogelstein, Kenneth W Kinzler, None, Identification of c-MYC as a Target of the APC Pathway Science. ,vol. 281, pp. 1509- 1512 ,(1998) , 10.1126/SCIENCE.281.5382.1509
Raynoo Thanan, Mariko Murata, Ning Ma, Olfat Hammam, Mohamed Wishahi, Tarek El Leithy, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi, Nuclear Localization of COX-2 in relation to the Expression of Stemness Markers in Urinary Bladder Cancer Mediators of Inflammation. ,vol. 2012, pp. 165879- 165879 ,(2012) , 10.1155/2012/165879
Yelena Y. Janjigian, Laura H. Tang, Daniel G. Coit, David P. Kelsen, Todd D. Francone, Martin R. Weiser, Suresh C. Jhanwar, Manish A. Shah, MET Expression and Amplification in Patients with Localized Gastric Cancer Cancer Epidemiology, Biomarkers & Prevention. ,vol. 20, pp. 1021- 1027 ,(2011) , 10.1158/1055-9965.EPI-10-1080