Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

摘要: The vertebrate zinc finger genes of the Gli family are homologs Drosophila gene cubitus interruptus. In frog embryos, Gli1 is expressed transiently in prospective floor plate during gastrulation and cells lateral to midline late gastrula neurula stages. contrast, Gli2 Gli3 absent from neural with widely a graded fashion highest levels regions. mouse three show similar pattern expression tube but coexpressed throughout early plate. Because only we have investigated possible involvement this ventral development. Here that Shh signaling activates transcription widespread endogenous or human glioma Gli1, not Gli3, developing embryos results ectopic differentiation neurons within tube. Floor-plate-inducing ability retained when cytoplasmic proteins forced into nucleus fused VP16 transactivating domain. Thus, our identify as target suggest it mediates induction by acting transcriptional regulator.