Is Triclosan a neurotoxic agent

摘要: Triclosan (TCS) is an antibacterial agent that has been used in many products since 1960s. Given its broad usage as antiseptic TCS present ubiquitously the environment. Trace levels of continue to be detected organisms, and it shown particularly toxic aquatic species. The mechanisms underlying TCS-mediated toxicity include hormone dyshomeostasis, induction oxidative stress, apoptosis inflammation. Although considered non-toxic mammals, adverse effects continuous, long-term low concentration exposure remain unknown. Epidemiological studies revealed human tissues, urine, plasma breast milk correlate with this antimicrobial. This led concerns regarding safety potential humans, special emphasis on early development. Food Drug Administration (FDA) recently issued a directive banning use consumer soaps, justifying move attributed data gaps effectiveness safety, indicating need for more addressing chemical-mediated various tissues including central nervous system (CNS). aim review was (1) summarize current findings neurotoxic given paucity data, (2) broaden discussion other TCS, which might plausibly related neuronal functions.