Triclosan and prescription antibiotic exposures and enterolactone production in adults.

摘要: Abstract Background The gut microbiome plays an important role in the development of disease. composition is influenced by factors such as mode delivery at birth, diet and antibiotic use, yet influence environmental chemical exposures largely unknown. antimicrobial compound triclosan, found many personal care products widely detected human urine, exposure for which systemic microbiotic effects may be particular interest. To investigate relationship between triclosan microflora, we assessed association enterolactone, intestinal metabolite that produced via bacterial transformation dietary lignans (seeds, nuts) has known susceptibility to oral antibiotics. Methods We examined urinary enterolactone 2005-2008 U.S. National Health Nutrition Examination Survey subjects, aged ≥20 years ( n =3041). also prescription use confirm its changes body. Associations natural log-transformed (1) vs. not Q 1– 5), (3) any no antibiotics were estimated with multiple linear regression, adjusting sex, age, race, body mass index, poverty income ratio, education, fiber intake, bowel movement frequency, cotinine creatinine =2441). Results Triclosan was 80% subjects (range: 99% β = 0.07 (95% CI: −0.15, 0.30); 5 (≥104.5 ng/mL) 1 (none): 0.06 −0.21, 0.34)). In sex-stratified analyses, associated higher women (detect non-detect: 0.31 −0.07, 0.70), but men −0.18 −0.47, 0.11). However, =112), compared significantly lower =−0.78 (95%CI: −1.22, −0.36)), sex-specific effects. This driven inverse associations following classes: macrolide derivatives, quinolones, sulfonamides, lincomycin derivatives. Conclusions Antibiotics, are negatively enterolactone. Antibiotics reduce killing certain bacteria. At levels U.S., does appear acting similarly, despite broad properties. Additional study determinants production needed better understand positive among women.