The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited
作者： Olga B. Chernova , Michail V. Chernov , Munna L. Agarwal , William R. Taylor , George R. Stark
DOI: 10.1016/S0968-0004(00)89094-5
关键词:
摘要: In addition to its induction by DNA damage, p53 is induced drugs that starve cells for and RNA precursors, or inhibitors of polymerase. normal cells, the dNTP starvation serves a protective role, mediating rapid, reversible cell-cycle arrest without damage. most cell lines, this first line defense missing, so dNTPs causes break, thus increasing probability genomic instability, chromosome deletions gene amplification. The mechanism how remains unclear.
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