The oral microbiota in colorectal cancer is distinctive and predictive.

摘要: Background and aims Microbiota alterations are linked with colorectal cancer (CRC) notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if mucosa-associated taxa indeed orally derived, such cases a distinct subset patients or the microbiome generally suitable for screening CRC. Methods We profiled microbiota in swabs, mucosae stool from individuals CRC (99 subjects), polyps (32) controls (103). Results Several were differentially abundant compared controls, example, Streptococcus Prevotellas pp. A classification model swab distinguished (sensitivity: 53% (CRC)/67% (polyps); specificity: 96%). Combining data faecal increased sensitivity this to 76% (CRC)/88% (polyps). detected similar bacterial networks datasets comprising biofilm forming bacteria. While these more CRC, core between pathogenic, CRC-associated as Peptostreptococcus, Parvimonas Fusobacterium also healthy controls. High Lachnospiraceae was negatively associated colonisation tissue oral-like suggesting protective role certain types against possibly by conferring resistance mediated through habitual diet. Conclusion The heterogeneity may relate that either predispose provide disease, profiling offer an alternative screen detecting