Anemia in heart failure patients.

作者: Michael G. Alexandrakis , George Tsirakis

DOI: 10.5402/2012/246915

关键词:

摘要: Heart failure is a very common disease, with severe morbidity and mortality, frequent reason of hospitalization. Anemia concurrent renal impairment are two major risk factors contributing to the severity outcome consist cardio anemia syndrome. in heart complex multifactorial. Hemodilution, absolute or functional iron deficiency, activation inflammatory cascade, impaired erythropoietin production activity some pathophysiological mechanisms involved failure. Furthermore other concomitant causes anemia, such as myelodysplastic syndrome chemotherapy, may worsen outcome. Based on pathophysiology cardiac there several therapeutic options that improve hemoglobin levels, tissues' oxygenation, probably These include administration iron, erythropoiesis-stimulating agents, blood transfusions but still evidence provided for their use remains limited.

参考文章(83)
Darlington O. Okonko, Amit K.J. Mandal, Constantinos G. Missouris, Philip A. Poole-Wilson, Disordered Iron Homeostasis in Chronic Heart Failure: Prevalence, Predictors, and Relation to Anemia, Exercise Capacity, and Survival Journal of the American College of Cardiology. ,vol. 58, pp. 1241- 1251 ,(2011) , 10.1016/J.JACC.2011.04.040
Hessel F. Groenveld, James L. Januzzi, Kevin Damman, Jan van Wijngaarden, Hans L. Hillege, Dirk J. van Veldhuisen, Peter van der Meer, Anemia and Mortality in Heart Failure Patients: A Systematic Review and Meta-Analysis Journal of the American College of Cardiology. ,vol. 52, pp. 818- 827 ,(2008) , 10.1016/J.JACC.2008.04.061
Darlington O. Okonko, Agnieszka Grzeslo, Tomasz Witkowski, Amit K.J. Mandal, Robert M. Slater, Michael Roughton, Gabor Foldes, Thomas Thum, Jacek Majda, Waldemar Banasiak, Constantinos G. Missouris, Philip A. Poole-Wilson, Stefan D. Anker, Piotr Ponikowski, Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial Journal of the American College of Cardiology. ,vol. 51, pp. 103- 112 ,(2008) , 10.1016/J.JACC.2007.09.036
Inder S. Anand, Anemia and Chronic Heart Failure: Implications and Treatment Options Journal of the American College of Cardiology. ,vol. 52, pp. 501- 511 ,(2008) , 10.1016/J.JACC.2008.04.044
Grace L. Smith, Judith H. Lichtman, Michael B. Bracken, Michael G. Shlipak, Christopher O. Phillips, Paul DiCapua, Harlan M. Krumholz, Renal Impairment and Outcomes in Heart Failure Journal of the American College of Cardiology. ,vol. 47, pp. 1987- 1996 ,(2006) , 10.1016/J.JACC.2005.11.084
Rania Gaber, Nesreen A. Kotb, Medhat Ghazy, Hala M. Nagy, Mai Salama, Abdou Elhendy, Tissue Doppler and strain rate imaging detect improvement of myocardial function in iron deficient patients with congestive heart failure after iron replacement therapy. Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques. ,vol. 29, pp. 13- 18 ,(2012) , 10.1111/J.1540-8175.2011.01532.X
Anatole Besarab, Managing anemia in patients with chronic heart failure: what do we know? Vascular Health and Risk Management. ,vol. 6, pp. 237- 252 ,(2010) , 10.2147/VHRM.S4619