Pharmacokinetics of albendazole sulfoxide enantiomers administered in racemic form and separately in rats.
作者： Bettencourt P.S. Capece , Gloria Castells , Carlo Godoy , Margarita Arboix , Carles Cristòfol
DOI: 10.1016/J.TVJL.2007.04.011
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摘要: Abstract The pharmacokinetic behaviour of albendazole sulfoxide (ABZSO) enantiomers was studied in rats after the oral administration 10 mg/kg rac-ABZSO, 5 mg/kg (−)-ABZSO or (+)-ABZSO. disposition profiles ABZSO were similar all treatments, but calculated area under curve for higher cases compared with results suggest that there is no chiral inversion enantiomers. After 17.2% total dose recovered urine as ABZ (0.1%), sulfone ABZSO2 (0.3%), 2-aminosulfone (ABZ-SO2NH2) (3.1%) and (13.7%). ratio (+) to (−) (1.6) blood (1.7).
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