The high-efficient production of phelligridin LA by Inonotus baumii with an integrated fermentation-separation process
作者： Tianwen Wang , Hui Li , Chen Liang , Shiwei Sun , Ao Liu
DOI: 10.1007/S00449-020-02310-Y
关键词:
摘要: The phelligridin LA was one of the valuable metabolites synthesized by medicinal fungus Sanghuang in liquid fermentation. In improvement PLA productivity fermentation, we investigated optimal conditions for efficient separation from fermentation broth with a chromatographic column packed macroporous resin ADS-17. Based on findings, further developed an integrated bioreactor system that coupled and PLA. Fermentation experiments testified performance our design fortification production: production 2.14 folds successfully achieved due to prompt removal PLA, while formation hyphae biomass not affected. Also, could afford simultaneous purification purity 92.95% recovery 84.3%, which comparable purified additional process (97.53%), at reasonable recovery. This study provided feasible approach improved Besides, offered useful reference development fungi diverse metabolites.
springer.com
sci-hub.se 参考文章(31)
Fanglong Zhao, Chuanbo Zhang, Jing Yin, Yueqi Shen, Wenyu Lu, Coupling of Spinosad Fermentation and Separation Process via Two-Step Macroporous Resin Adsorption Method Applied Biochemistry and Biotechnology. ,vol. 176, pp. 2144- 2156 ,(2015) , 10.1007/S12010-015-1704-1
Rimvydas Simutis, Andreas Lübbert, Bioreactor control improves bioprocess performance Biotechnology Journal. ,vol. 10, pp. 1115- 1130 ,(2015) , 10.1002/BIOT.201500016
Cecília Ladeira Lopes Costa, Alberto Colli Badino, Overproduction of clavulanic acid by extractive fermentation Electronic Journal of Biotechnology. ,vol. 18, pp. 154- 160 ,(2015) , 10.1016/J.EJBT.2015.03.001
Julian T. Dafoe, Andrew J. Daugulis, In situ product removal in fermentation systems: improved process performance and rational extractant selection Biotechnology Letters. ,vol. 36, pp. 443- 460 ,(2014) , 10.1007/S10529-013-1380-6
Sang Bae Han, Chang Woo Lee, Young Jin Jeon, Nam Doo Hong, Ick Dong Yoo, Kyu-Hwan Yang, Hwan Mook Kim, The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis Immunopharmacology. ,vol. 41, pp. 157- 164 ,(1999) , 10.1016/S0162-3109(98)00063-0
D Sliva, A Jedinak, J Kawasaki, K Harvey, V Slivova, Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling British Journal of Cancer. ,vol. 98, pp. 1348- 1356 ,(2008) , 10.1038/SJ.BJC.6604319
Y. Hu, H.-L. Xin, Q.-Y. Zhang, H.-C. Zheng, K. Rahman, L.-P. Qin, Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents. Phytomedicine. ,vol. 14, pp. 668- 674 ,(2007) , 10.1016/J.PHYMED.2007.01.008
F. R. Schmidt, Optimization and scale up of industrial fermentation processes Applied Microbiology and Biotechnology. ,vol. 68, pp. 425- 435 ,(2005) , 10.1007/S00253-005-0003-0
Yan Sun, Hongyan Yuan, Lili Hao, Chunyan Min, Jinna Cai, Jiangyun Liu, Peilie Cai, Shilin Yang, Enrichment and antioxidant properties of flavone C-glycosides from trollflowers using macroporous resin. Food Chemistry. ,vol. 141, pp. 533- 541 ,(2013) , 10.1016/J.FOODCHEM.2013.03.030
Gabriela Furlan Giordano, Luis Carlos Silveira Vieira, Angelo Luiz Gobbi, Renato Sousa Lima, Lauro Tatsuo Kubota, An integrated platform for gas-diffusion separation and electrochemical determination of ethanol on fermentation broths. Analytica Chimica Acta. ,vol. 875, pp. 33- 40 ,(2015) , 10.1016/J.ACA.2015.03.014