Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer.
作者： Marianne Nordsmark , Jens Overgaard
DOI: 10.1080/02841860410026189
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摘要: There is evidence that tumor hypoxia adversely affects loco-regional control and survival in head neck cancer. The aim of the current study was to compare pretreatment oxygenation measured by Eppendorf pO2 electrodes with known prognostic factors advanced tumors after definitive radiotherapy, evaluate significance these parameters on control. Sixty-seven patients, median age 56 years (22-82), all primary stage III-IV squamous cell carcinoma were available for analysis. Tumor described as fraction values < or = 2.5 mmHg (HP2.5) pO2. By regression analysis HP2.5 independent including stage, hemoglobin (Hb) largest diameter at site measurement. Kaplan-Meier 5 favor less hypoxic using either descriptors stratifying values. Also, Hb value cut off. continuous parameter highly significant a multivariate In conclusion both total control, but variable independently strongest indicator radiotherapy tumors.
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