Low miR-192 expression predicts poor prognosis in pediatric acute myeloid leukemia.
作者： Chunmei Tian , Lin Zhang , Xiaohua Li , Yanjun Zhang , Jianchang Li
DOI: 10.3233/CBM-170657
关键词:
摘要: Background Abnormal expression of miR-192 has been observed in a variety human cancers, but the pattern and its prognostic value pediatric acute myeloid leukemia (AML) is poorly known. Objective This study was to explore status clinical significance patients with AML. Methods Quantitative RT-PCR carried out detect level serum from 97 AML cases 50 healthy controls. Results The results showed that downregulation strongly correlated aggressive features. Increased occurred more frequently subjects favorable risk cytogenetics. Moreover, good performance screen normal Furthermore, identified as independent indicator for both overall survival event free survival. In addition, low significantly contributed poor prognosis whole cohort or intermediate-risk Conclusions Collectively, potentially can be reliable biomarker diagnosis
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