Thrombosis in Systemic Lupus Erythematosus

摘要: • In an earlier report on the kidney in systemic lupus erythematosus (SLE), we described a subset of patients with circulating anticoagulants; many had glomerular and arteriolar thrombosis absence necrosis subendothelial deposits. The present study extends these observations to larger group SLE anticoagulant, compares its findings those without evidence anticoagulant. It demonstrates (1) higher prevalence clinically recognizable thrombotic events venous arterial circulations detectable anticoagulant; (2) probable shortening life span; (3) thrombi; (4) elevated levels factor VIII antigen von Willebrand factor; (5) significantly lower platelet counts decreased vitro aggregration response adenosine diphosphate, epinephrine, collagen. Since prednisone treatment often results improvement or disappearance prolonged partial thromboplastin time, test most commonly used for screening suggest that this abnormality may be underestimated SLE. ( Arch Intern Med 1985;145:1389-1395)