Functional repair of critically sized femoral defects treated with bioinspired titanium gyroid-sheet scaffolds.

摘要: Despite the innate ability for bone to remodel and repair, its regeneration has a limit. In these cases of critically sized defects (CSBD), deficit must be repaired using reconstructive techniques that support immediate load bearing encourage bridging across defect. High-strength porous titanium implants offer solution treatment CSBD in which scaffold can physiological loads, provide matrix guide ingrowth, carry graft materials and/or biologics. Fabrication meta-materials via additive manufacturing (AM) unlocked potential modulate mechanical biological performance achieve combination properties previously unachievable. Meta-material scaffolds with topology based on triply periodic minimal surfaces (TPMS) have gained increasing interest use biomedical applications due their bioinspired nature. enthusiasm TPMS-based high strength stiffness ratio, permeability, curvature similar trabecular bone, there is little preclinical evidence vivo response bone. The present study sought evaluate gyroid-sheet produced AM repair size femoral cortical defect rats. Empty were shown segmental up 38% torsional 54% intact femur (control) at 12-weeks. Gyroid-sheet carrying recombinant morphogenic protein-2 demonstrated growth length defect, superior controls.