Expression and Cellular Localization of 15-Hydroxy-Prostaglandin-Dehydrogenase in Abdominal Aortic Aneurysm
作者： David Solà-Villà , Jaime-Félix Dilmé , Cristina Rodríguez , Begoña Soto , Luis Vila
DOI: 10.1371/JOURNAL.PONE.0136201
关键词:
摘要: PGE2 has been implicated in abdominal aortic aneurysm (AAA) associated hypervascularization. PGE2-metabolism involves 15-hydroxyprostaglandin-dehydrogenase (15-PGDH) the expression of which AAA is unknown. The aim this study was to examine and cell distribution 15-PGDH AAA. Here, we show that mRNA levels were significantly higher aorta samples from patients undergoing repair than those healthy multiorgan donors. Consequently, ratio metabolized secreted by production total metabolites correlated positively with PGI2 production, while percentage negatively amount PGI2. Transcript statistically leukocyte markers but did not correlate microvascular endothelial markers. Immunohistochemistry revealed areas infiltration samples, mainly CD45-positive cells, normal samples. We provide new data concerning human AAA, showing upregulated expressed infiltrating leukocytes. Our suggest microvasculature involved catabolism, reinforcing potential role derived AAA-associated
harvard.edu
paperity.org参考文章(29)
G S Herron, E Unemori, M Wong, J H Rapp, M H Hibbs, R J Stoney, Connective tissue proteinases and inhibitors in abdominal aortic aneurysms. Involvement of the vasa vasorum in the pathogenesis of aortic aneurysms. Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 11, pp. 1667- 1677 ,(1991) , 10.1161/01.ATV.11.6.1667
Bernice Cheuk, Stephen Cheng, Differential secretion of prostaglandin E(2), thromboxane A(2) and interleukin-6 in intact and ruptured abdominal aortic aneurysms. International Journal of Molecular Medicine. ,vol. 20, pp. 391- 395 ,(2007) , 10.3892/IJMM.20.3.391
Hsin-Hsiung Tai, Charles Mark Ensor, Min Tong, Huiping Zhou, Fengxiang Yan, Prostaglandin catabolizing enzymes Prostaglandins & Other Lipid Mediators. ,vol. 68-69, pp. 483- 493 ,(2002) , 10.1016/S0090-6980(02)00050-3
Ian M. Nordon, Robert J. Hinchliffe, Ian M. Loftus, Matt M. Thompson, Pathophysiology and epidemiology of abdominal aortic aneurysms Nature Reviews Cardiology. ,vol. 8, pp. 92- 102 ,(2011) , 10.1038/NRCARDIO.2010.180
Kelly Casós, Laura Siguero, María-Teresa Fernández-Figueras, Xavier León, María-Pilar Sardá, Luis Vila, Mercedes Camacho, Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation. Microvascular Research. ,vol. 81, pp. 261- 268 ,(2011) , 10.1016/J.MVR.2011.01.006
Mercedes Camacho, Luı́s Vila, Transcellular Formation of Thromboxane A2 in Mixed Incubations of Endothelial Cells and Aspirin-Treated Platelets Strongly Depends on the Prostaglandin I-Synthase Activity Thrombosis Research. ,vol. 99, pp. 155- 164 ,(2000) , 10.1016/S0049-3848(00)00241-3
David C Paik, Chenzhong Fu, Jahar Bhattacharya, M David Tilson, Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm. Experimental and Molecular Medicine. ,vol. 36, pp. 524- 533 ,(2004) , 10.1038/EMM.2004.67
Dennis R. Holmes, William Wester, Robert W. Thompson, Jeffrey M. Reilly, Prostaglandin E2 synthesis and cyclooxygenase expression in abdominal aortic aneurysms Journal of Vascular Surgery. ,vol. 25, pp. 810- 815 ,(1997) , 10.1016/S0741-5214(97)70210-6
K.S. Chapple, D.J. Parry, S. McKenzie, K.A. MacLennan, P. Jones, D.J.A. Scott, Cyclooxygenase-2 Expression and Its Association with Increased Angiogenesis in Human Abdominal Aortic Aneurysms Annals of Vascular Surgery. ,vol. 21, pp. 61- 66 ,(2007) , 10.1016/J.AVSG.2006.10.008
Mercedes Camacho, Zenaida Piñeiro, Sonia Alcolea, Jacinto García, Josep Balart, Ximena Terra, Francesc-Xavier Avilés-Jurado, Marta Soler, Miquel Quer, Xavier León, Luis Vila, Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy. The Journal of Pathology. ,vol. 235, pp. 125- 135 ,(2015) , 10.1002/PATH.4453