Anti-Helicobacterpylori effectiveness and targeted delivery performance of amoxicillin-UCCs-2/TPP nanoparticles based on ureido-modified chitosan derivative.
作者： Zi-Wei Jing , Min Luo , Yi-Yang Jia , Chen Li , Si-Yuan Zhou
DOI: 10.1016/J.IJBIOMAC.2018.04.070
关键词:
摘要: The amoxicillin-UCCs-2/TPP nanoparticles constructed with ureido-modified chitosan derivative UCCs-2 and sodium tripolyphosphate (TPP) played an important role to deliver drug achieve more efficacious specific eradication of Helicobacterpylori (H. pylori) in vitro. In this study, the anti-H. pylori effectiveness vivo uptake mechanism was investigated details, including effect temperature, pH values addition competitive substrate urea on uptake. Compared unmodified nanoparticles, a activities were obtained by using biological UCCs-2. Histological staining immunological analysis verified that could diminish proinflammatory cytokines levels alleviate inflammatory damages caused H. infection. uredio-modified also have favorable gastric retention property, which is beneficial for oral delivery targeted eradicate infection stomach. These findings suggest system may serve treatment both vitro vivo, can be used as promising nanocarriers other therapeutic reagents target pylori.
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