An inconvenient truth: global worming and anthelmintic resistance.

摘要: Over the past 10-15 years, we have witnessed a rapid increase in both prevalence and magnitude of anthelmintic resistance, this appears to be worldwide phenomenon. Reports resistance multiple drugs individual parasite species, species across virtually all livestock hosts, are increasingly common. In addition, since introduction ivermectin 1981, no novel classes were developed introduced for use until recently with launch monepantel New Zealand. Thus, producers often left few options effective treatment against many important species. While new mechanisms action could potentially solve problem, extremely expensive develop, can expected more than older drugs. it seems clear that "Global Worming" approach has taken hold over 40-50 years must change, develop vision control sustainability production. Furthermore, parasitologists improve methods study design data analysis used diagnosing especially fecal egg count reduction test (FECRT). Currently, standards diagnosis using FECRT exist only sheep. Lack horses cattle arbitrarily defined cutoffs defining combined inadequate data, mean errors assigning status Similarly, lack makes difficult compare among different studies. This problem needs addressed, because as now future, alternative treatments will make early accurate important.