Evaluating the Human Response to Sensory Irritation: Implications for Setting Occupational Exposure Limits

摘要: Although animal models of sensory irritation have led to the development useful assays for evaluating potency chemical irritants, importance conducting human exposure studies model and understand response irritants cannot be minimized. In recent years a series tests been developed humans that can safely conducted provide excellent data on which base occupational limits. This article delineates major issues involved in evaluations humans. Among these are differences between odor irritation, slight toxicity, adaptation habituation, as well personal expectation about discomfort reported irritation. The also describes psychophysiological electrophysiological methods assessing Some possible confounders influence results involving addressed.