Divergent profile between hypothalamic and plasmatic aminopeptidase activities in WKY and SHR. Influence of beta-adrenergic blockade.

摘要: Abstract Aims Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) differ in their renin-angiotensin system function sympathetic tone. The metabolism of angiotensins vasopressin depends on the action certain aminopeptidases whose activity may be influenced by autonomic nervous system. Their regulation between WKY SHR hypothalamus plasma according to We analyzed responsible for hydrolysis angiotensins, vasopressin, cholecystokinin or enkephalins untreated controls under beta-adrenoceptor blockade. Systolic blood pressure, food intake, water intake diuresis were measured as parameters modulated above mentioned peptides. Main methods Glutamyl-, aspartyl-, cystinyl- alanyl-aminopeptidase activities fluorimetrically control propranolol-treated (100 mg/kg/day administered drinking 1 month) SHR, using arylamide derivatives substrates. Key findings An opposite response propranolol treatment was observed either SHR. Furthermore, behavior inversed plasma: while increased decreased WKY, it Significance These results revealed an inverse also these enzymes plasma. observations support involvement modulation aminopeptidase activities.