Thyroid Disorders Change the Pattern of Response of Angiotensinase Activities in the Hypothalamus-Pituitary-Adrenal Axis of Male Rats.
作者： Ana B Segarra , Isabel Prieto , Magdalena Martínez-Cañamero , Marc De Gasparo , Juan de Dios Luna
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摘要: Thyroid disorders affect the hypothalamic-pituitary-adrenal (HPA) axis with important consequences on cardiovascular function in which renin-angiotensin system (RAS) plays a major role. Hypo and hyperthyroidism influence classic main components of RAS. However, behavior other RAS elements like Ang III, 2-10, IV or AT4, regulated by angiotensinase enzymes such as alanyl- (AlaAP), cystinyl- (CysAP), glutamyl- (GluAP) aspartyl-aminopeptidase (AspAP), has not yet been described. In order to obtain comprehensive view response HPA animals thyroid disorders, these enzyme activities were simultaneously analyzed fluorometrically, using arylamide derivatives substrates hypothalamus, anterior posterior pituitary, adrenals plasma eu- (EU)- hypo- (HYPO) hyperthyroid rats (HYPER), their intra- inter-tissue interactions evaluated. The depended type studied, its location status. Anterior mainly affected disorders. GluAP AspAP increased HYPO. adrenals, AlaAP CysAP decreased HYPO whereas HYPER. plasma, while HYPER, only comparison EU, intra-tissue correlations but both also produced disruption pattern observed EU. These results suggest that hormone levels hit may paracrine endocrine cross talk between cells.
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