Does growth hormone therapy in adult patients with growth hormone deficiency protect against bone loss

摘要: Fracture incidence is increased in growth hormone deficiency (GHD). However, the efficacy of (GH) prevention fractures GHD not documented. GH important to attain normal peak bone mass; it increases mass children and adolescents, but less with increasing age insignificant above 55-60 years old. Placebo-controlled trials 12 months' duration have failed improve density, while uncontrolled studies suggested that treatment for 2-4 may increase by 0.5 a standard deviation adults. Given current high price treatment, however, routine substitution intention decrease fracture adult patients likely be cost effective. should probably extended until has been achieved, repeated dual energy X-ray scan measurements intervals 1-2 could helpful deciding when stop treatment.