Involvement of immune cells in regulation of ovarian function.

摘要: Primary cultures of luteal cells have been used to determine both acute and chronic effects cytokines on cell function viability. Gonadotrophin-stimulated progesterone production is inhibited by interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), or gamma-interferon (IFN-gamma), the last two cytokine being more effective than IL-1. In contrast, all three are potent stimulators prostaglandin these cells. The mechanism which synthesis enhanced may differ slightly for each cytokine. cells, TNF-alpha appears act primarily through stimulation phospholipase A2, whereas IL-1 activate C endoperoxide synthase (PGS) in addition A2. action IFN-gamma has not yet determined. observed functional effects, also promote death during regression. Although mentioned little no effect viability cultured when administered separately, combined treatment with results a substantial decrease number viable Inhibition cytokine-stimulated does alter cytotoxic cytokines. Expression major histocompatibility (MHC) class I molecules enhanced, MHC II induced, exposure IFN-gamma. This especially intriguing, as expression increases before regression vivo, suppressed early pregnancy. summary, evidence rapidly accumulating that supports hypothesis structural integrity be modulated resident immune Future research will probably address how local events hormonally controlled, if they can modified regulate corpus luteum function.