Comparisons of the efficacy and tolerability of mycophenolate mofetil and azathioprine as treatments for neuromyelitis optica and neuromyelitis optica spectrum disorder

摘要: Background and purpose To research compare the efficacy tolerability of mycophenolate mofetil (MMF) azathioprine (AZA) in neuromyelitis optica (NMO) NMO spectrum disorder (NMOSD). Methods In this observational study, we enrolled patients with NMO/NMOSD who received either MMF or AZA for 6 months more. We compared as preventive treatments NMO/NMOSD. Results Baseline variables between groups were not significantly different. In MMF-treated (n = 105) AZA-treated groups, 56.2% 52.4%, respectively, relapse-free, both median annualized relapse rates Expanded Disability Status Scale scores lower (P 0.000). More than group stopped switched to another treatment because adverse effects. The at final follow-up group, duration after was longer more concurrently used prednisone 0.05) nor Cox proportional hazard model > indicated a significant difference MMF- groups. Conclusions Both effective NMO/NMOSD. Fewer mild events attributed AZA. probability maintaining relapse-free state different groups. However, acceptable safety profiles are still needed.