Oxygen Radicals and Hydroperoxides in Mammalian Organs: Aspects of Redox Cycling and Hydrogen Peroxide Metabolism

摘要: The 1968 conference on the Biochemistry of Oxygen (Hess and Staudinger 1968) contained only formal reference to reduction states oxygen such as one-electron, two-electron, or three-electron states. Time was surprisingly short between initial recurrence interest in biological chemistry metabolites about one two decades ago recent efforts, largely successful, applications new knowledge clinical medicine (Bannister Bannister 1980). In 1966, peroxisome described a subcellular organelle occupied, particular, with hydrogen peroxide metabolism (De Duve Baudhuin 1966). 1969, field free radicals received major stimulus discovery superoxide dismutase activity erythrocuprein (McCord Fridovich 1969). 1970, steady state production mammalian organs found occur normal attribute aerobic life (Sies Chance 1970; et al. 1979).