Oxidation of heme proteins as a measure of oxidative damage to liver tissue slices.
作者： Hao Chen , A.L. Tappel , Rowena C. Boyle
DOI: 10.1016/0891-5849(93)90108-7
关键词:
摘要: Abstract Oxidative damage to heme proteins in rat liver tissue slices was studied. Tissue were incubated KrebsRinger phosphate (KRP) buffer at 37°C with and without the presence of prooxidants. The absorbance spectra (500–640 nm) obtained from both spontaneous prooxidant-induced oxidation analyzed a protein analysis program (HPSAP) development this laboratory. dominant fresh nonperfused slice hemoglobin reduced cytochromes mitochondria. In an oxidized slice, major product hemichrome. Bromotrichloromethane, t -butyl hydroperoxide, ferrous ion accelerated oxidative reactions, amount products dependent on incubation time as well type concentration
elsevier.com
sci-hub.se 参考文章(42)
E. Cadenas, R. Brigelius, Th. Akerboom, H. Sies, Oxygen Radicals and Hydroperoxides in Mammalian Organs: Aspects of Redox Cycling and Hydrogen Peroxide Metabolism Biological Oxidations. pp. 288- 310 ,(1983) , 10.1007/978-3-642-69467-7_18
Mark K. Shigenaga, Jeen-Woo Park, Kenneth C. Cundy, Carlos J. Gimeno, Bruce N. Ames, [54] In vivo oxidative DNA damage : measurement of 8-hydroxy-2'-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection Methods in Enzymology. ,vol. 186, pp. 521- 530 ,(1990) , 10.1016/0076-6879(90)86146-M
Walter W. Wainio, The mammalian mitochondrial respiratory chain ,(1970)
Bernard G. Forget, H. Franklin Bunn, Hemoglobin: Molecular, Genetic and Clinical Aspects ,(1984)
O. W. van Assendelft, Spectrophotometry of haemoglobin derivatives ,(1970)
SPECTROPHOTOMETRIC STUDIES X. STRUCTURAL INTERPRETATION OF THE SPECTRA OF CYANIDE, PYRIDINE, AND CARBON MONOXIDE DERIVATIVES OF CYTOCHROME C AND HEMOGLOBIN Journal of Biological Chemistry. ,vol. 146, pp. 605- 617 ,(1942) , 10.1016/S0021-9258(18)44985-X
Robert E. Pacifici, Kelvin J.A. Davies, Protein degradation as an index of oxidative stress. Methods in Enzymology. ,vol. 186, pp. 485- 502 ,(1990) , 10.1016/0076-6879(90)86143-J
Takashi Yonetani, Heinz Schleyer, Studies on Cytochrome c Peroxidase IX. THE REACTION OF FERRIMYOGLOBIN WITH HYDROPEROXIDES AND A COMPARISON OF PEROXIDE-INDUCED COMPOUNDS OF FERRIMYOGLOBIN AND CYTOCHROME c PEROXIDASE Journal of Biological Chemistry. ,vol. 242, pp. 1974- 1979 ,(1967) , 10.1016/S0021-9258(18)96096-5
Toshikazu Noguchi, Kuo-Lan Fong, Edward K. Lai, Larry Olson, Paul B. Mccay, Selective early loss of polypeptides in liver microsomes of CCl4-treated rats. Relationship to cytochrome P-450 content. Biochemical Pharmacology. ,vol. 31, pp. 609- 614 ,(1982) , 10.1016/0006-2952(82)90439-7
R L Aft, G C Mueller, Hemin-mediated oxidative degradation of proteins. Journal of Biological Chemistry. ,vol. 259, pp. 301- 305 ,(1984) , 10.1016/S0021-9258(17)43657-X